Publications

‘Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens’
Ryan Cook, Steve Hooton, Urmi Trivedi, Liz King, Christine E.R. Dodd Jon L. Hobman, Dov J. Stekel, Michael A. Jones, Andrew D. Millard
Microbiome (20 March 2021) https://doi.org/10.1186/s40168-021-01010-3

‘Genomic network analysis of environmental and livestock F-type plasmid populations’
William Matlock, Kevin Chau, Manal AbuOun, Emma Stubberfield, Leanne Barker, James Kavanagh, Hayleah Pickford, Daniel Gilson, Richard P. Smith, H. Soon Gweon, Sarah J. Hoosdally, Jeremy Swann, Robert Sebra, Mark J. Bailey, Timothy E. A. Peto, Derrick W. Crook, Muna F. Anjum, Daniel S. Read, A. Sarah Walker, Nicole Stoesser, Liam P. Shaw & REHAB consortium
The ISME Journal (1 March 2021) https://doi.org/10.1038/s41396-021-00926-w

‘Flanker: a tool for comparative genomics of gene flanking regions’
William Matlock, Samuel Lipworth, Bede Constantinides, Timothy E.A. Peto, A. Sarah Walker, Derrick Crook, Susan Hopkins, Liam P. Shaw, Nicole Stoesser
bioRxiv (22 February 2021) https://doi.org/10.1101/2021.02.22.432255

‘L1000 connectivity map interrogation identifies candidate drugs for repurposing as
SARS-CoV-2 antiviral therapies’
Wezi Sendama
Computational and Structural Biotechnology Journal (2020, 18)
https://doi.org/10.1016/j.csbj.2020.11.054

‘Overuse of antibiotics: Can viral vaccinations help stem the tide?
Lucy Miller, Ceire E. Costelloe, Julie V. Robotham and Koen B. Pouwels
British Journal of Clinical Pharmacology (2020; 1-3) https://doi.org/10.1111/bcp.14651  

‘Molecular epidemiology of Escherichia coli producing CTX-M and plasmid AmpC-type β-lactamases from dairy farms identifies a dominant plasmid encoding CTX-M-32 but no evidence for transmission to humans in the same geographical region’
Jacqueline Findlay, Oliver Mounsey, Winnie W. Y. Lee, Nerissa Newbold, Katy Morley, Hannah Schubert, Virginia C. Gould, Tristan A. Cogan, Kristen K. Reyher and Matthew B. Avison
Applied and Environmental Microbiology (2020) https://doi.org/10.1128/AEM.01842-20

‘Wastewater surveillance of antimicrobial resistance in human populations: A systematic review’
Kevin Chau, Leanne Barker, Natalie Sims, Barbara Kasprzyk-Hordern, Eric Budgell, Elinor Harriss, Derrick Crook, Daniel Read, Sarah Walker and Nicole Stoesser
Preprints (13 October 2020) https://doi.org/10.20944/preprints202010.0267.v1

‘Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens’
Ryan Cook, Steven Hooton, Urmi Trivedi, Liz King, Christine Dodd, Jon Hobman, Dov J. Stekel, Michael Jones and Andrew D. Millard.
bioRxiv (8 October 2020) https://doi.org/10.1101/2020.10.08.329714

‘Proteomics identifies a type 1 IFN, prothrombotic hyperinflammatory circulating COVID-19 neutrophil signature distinct from non-COVID-19 ARDS’
Leila Rayes, Manuel Alejandro Sanchez-Garcia, Tyler Morrison, Andrew JM Howden, Emily R Watta, Simone Arienti, Pranvera Sadiku, Patricia Coelho, Ananda S Mirchandani, David Hope, Sarah K Clark, Jo Singleton, Shonna Johnston, Robert Grecian, Azin Poon, Sarah McNamara, Isla Harper, Max Head Fourman, Alejandro J Brenes, Shalini Pathak, Amy Lloyd, Gio Rodriguez Blanco, Alex Von Kriegsheim, Bart Ghesquiere, Wesley Vermaelen, Camilla T Cologna, Kevin Dhaliwal, Nik Hirani, David Dockrell, Moira KB Whyte, David M Griffith, Doreen A Cantrell and Sarah R Walmsley.
medRxiv (18 September 2020) https://doi.org/10.1101/2020.09.15.20195305

‘Differential occupational risks to healthcare workers from SARS-CoV-2: A prospective observational study’
David W. Eyre, Sheila Lumley, Denise O’Donnell, Mark Campbell, Elizabeth Sims, Elaine Lawson, Fiona Warren, Tim J. James, Stuart Cox, Alison Howarth, George Doherty, Stephanie B. Hatch, James Kavanagh, Kevin. K Chau, Philip W. Fowler, Jeremy Swann, Denis Volk, Dan Yang-Turner, Nicole Stoesser and 33 others
medRxiv (29 June 2020) https://doi.org/10.1101/2020.06.24.20135038

‘Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β‐Lactamase from Escherichia coli’
Pauline A. Lang, Anete Parkova, Thomas M. Leissing, Karina Calvopiña, Ricky Cain, Alen Krajnc,  Tharindi D. Panduwawala, Jules Philippe, Colin W. G. Fishwick, Peteris Trapencieris, Malcolm G. P. Page, Christopher J. Schofield and Jürgen Brem
Biomolecules 2020, 10, 899; http://doi:10.3390/biom10060899

‘The Effect of Ageing on the Resolution of Inflammation’
Wezi Sendama
Ageing Research Reviews 57 (2020) 101000; https://doi.org/10.1016/j.arr.2019.101000

‘Storytelling as a research tool and intervention around public health perceptions and behaviour: a protocol for a systematic narrative review’
Becky McCall,  Laura Shallcross, Michael Wilson, Christopher Fuller and Andrew Hayward
BMJ Open (2019); 9:e030597; https://doi:10.1136/bmjopen-2019-030597

‘Regulation of Apoptotic Cell Clearance During Resolution of Inflammation’
Simone Arienti, N.D. Barth, D.A. Dorwood, A.G. Rossi and I. Dransfield
Front. Pharmacol (2019): 10:891; https://doi:10.3389/fphar.2019.00891

‘The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and Staphylococcus aureus
Natalia H. Hajdamowicz, Rebecca C. Hull, Simon J. Foster and Alison M. Condliffe 

Int. J. Mol. Sci. (2019) 20, 5561; https://doi:10.3390/ijms20225561

‘Will Morphing Boron-Based Inhibitors Beat the β-lactamases?’

Alen Krajnc*, Pauline A. Lang*, Tharindi D. Panduwawala*, Jürgen Brem* and Christopher J. Schofield* (*authors contributed equally).
Current Opinion in Chemical Biology (2019) 50; https://doi.org/10.1016/j.cbpa.2019.03.001

‘Targeting the Mycobacterium tuberculosis Transpeptidase LdtMt2 with Cysteine-Reactive Inhibitors including Ebselen’
Mariska de Munnik, Christopher T. Lohans, Pauline A. Lang, Gareth W. Langley, Tika R. Malla, Anthony Tumber, Christopher J. Schofield and Jürgen Brem.
Chem. Commun. (2019) 55, 69; https://doi.org/10.1039/C9CC04145A

‘Molecular Basis of Class A β-lactamase Inhibition by Relebactam’
Catherine L. Tooke, Philip Hinchliffe, Pauline A. Lang, Adrian J. Mulholland, Jürgen Brem, Christopher J. Schofield and James Spencer.
Antimicrobial Agents and Chemotherapy (2019); https://doi.org/10.1128/AAC.00564-19

‘Mapping the Hydrophobic Substrate Binding Site of Phenylalanine Ammonia Lyase from Petroselinum crispum’
Emma Zsófia Aletta Nagy, Diana Souad Tork, Pauline A. Lang, Alina Filip, Florin Dan Irimie,  László Poppe et al.
ACS Catalysis. (2019); https://doi.org/10.1021/acscatal.9b02108